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KMID : 0365719990150010079
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Journal of Pusan Surgical Society
1999 Volume.15 No. 1 p.79 ~ p.85
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Preliminary Results of Change of Expression of Angiogenic Factors According to Stage in Gastric Cancer
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Lim Hyun-Sung
Kim Hyung-Ho
Choi Hong-Jo
Kim Young-Hoon
Joh Se-Heon
Jung Ghap-Joong
Kim Sang-Sun
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Abstract
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Background: It has been suggested that the expression of angiogenic factors by tumor cells contributes to the increased neovascularization and vessel permeability that are associated with tumor vasculature. However, the significance of protein expression involving tumor angiogenesis in gastric cancer has yet not to be classified.
Methods: In this study, the expression of vascular endothelial growth factor (VEGF), cyclooxygenase (Cox), and nitric oxide synthase (NOS) were investigated in surgically resected 14 human gastric carcinomas by western blotting.
Result: In 6 cases of the 14 paired cases, VEGF expression in tumor tissue was slightly increased as compared with nonneoplastic counterpart in same specimen. However, The expression of inducible type Cox-2 was significantly increased but constitetive type Cox-1 was decreased in tumor tissues. The expression of endothelial type eNOS in cancer tissue was shown to be higher than in normal gastric resected tissues, but the expression of nNOS in cancer was contrastly lower than normal gastric mucosa.
Conclusion: However, a direct positive correlation between VEGF expression and Table 1. vase or nitric oxide synthase was not found in different stages of gastric tumor cyclooxygent role in No development. The cyclooxygenase and nitric oxide synthase, may thus play an imPocta 1 gastric cancer development.
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KEYWORD
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VEGF, Cyuclooxygenase, NOS, Gastric cancer
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